ENDOCRINE AND NEUROENDOCRINE TUMOURS WHO CLASSIFICATION OF TUMOURS 5TH

ENDOCRINE AND NEUROENDOCRINE TUMOURS - WHO CLASSIFICATION OF TUMOURS 5TH Edition

Volume 10

  • Nouveauté
"Endocrine and Neuroendocrine Tumours" is Volume 10 in the 5th edition of the WHO series on the classification of human tumours.

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Auteur(s) International Agency for Research IARC
Éditeur WHO
Date 27/03/2025
Taille 21 x 27
Type Broché
ISBN 9789283245247

Description détaillée : ENDOCRINE AND NEUROENDOCRINE TUMOURS - WHO CLASSIFICATION OF TUMOURS 5TH Edition

This series (also known as the WHO Blue Books) is regarded as the gold standard for the diagnosis of tumours and comprises a unique synthesis of histopathological diagnosis with digital and molecular pathology.

These authoritative and concise reference books provide indispensable international standards for anyone involved in the care of patients with cancer or in cancer research, underpinning individual patient treatment as well as research into all aspects of cancer causation, prevention, therapy, and education.

What’s new in this edition?

The 5th edition, guided by the WHO Classification of Tumours Editorial Board, establishes a single coherent cancer classification presented across a collection of individual volumes organized on the basis of anatomical site (digestive system, breast, soft tissue and bone, etc.) and structured in a systematic manner, with each tumour type listed within a taxonomic classification: site, category, family (class), type, and subtype.

In each volume, the entities are now listed from benign to malignant and are described under an updated set of headings, including histopathology, diagnostic molecular pathology, staging, and easy-to-read essential and desirable diagnostic criteria.

Who should read this book?

  •     Pathologists
  •     Endocrinologists
  •     Medical oncologists
  •     Surgical oncologists
  •     Radiation oncologists
  •     Radiologists
  •     Nuclear medicine specialists
  •     Molecular pathologists
  •     Geneticists
  •     Immunologists
  •     Cancer researchers
  •     Epidemiologists
  •     General practitioners
  •     Oncology nurses
  •     Cancer registrars

This volume

  •     Prepared by 175 authors and editors
  •     Contributors from around the world
  •     More than 1100 high-quality images
  •     More than 5100 references

À PARAÎTRE OU DERNIÈRE PARUTION DANS LA MÊME CATÉGORIE :

Sommaire : ENDOCRINE AND NEUROENDOCRINE TUMOURS - WHO CLASSIFICATION OF TUMOURS 5TH Edition

Table of contents

  • List of abbreviations x
  • Foreword xi
  • ICD-O topographical coding 1
  • ICD-O morphological coding 4
  • Pituitary tumours 5
  • Thyroid tumours 7
  • Parathyroid tumours 9
  • Adrenal gland tumours 10
  • Adrenal medulla and extra-adrenal paraganglia tumours 11
  • Pancreatic neuroendocrine neoplasms 12
  • Neuroendocrine neoplasms in non-endocrine organs 13
  • Mesenchymal and stromal tumours 14
  • Haematolymphoid tumours 16
  • Germ cell tumours 17
  • TNM staging of endocrine and neuroendocrine tumours 18
  • Carcinomas of the thyroid gland 18
  • Carcinomas of the adrenal cortex 20
  • Tumours of the pancreas 21
  • Well-differentiated neuroendocrine tumours of the gastrointestinal tract 22

1 Introduction to endocrine and neuroendocrine tumours 28

2 Pituitary tumours 33

  • Introduction 34
  • Anterior pituitary neuroendocrine tumours (PitNETs)
  • PitNETs of PIT1 lineage
  • Somatotroph PitNET/adenoma 40
  • Mammosomatotroph PitNET/adenoma 45
  • Lactotroph PitNET/adenoma 48
  • Thyrotroph PitNET/adenoma 53
  • Mature plurihormonal PIT1-lineage PitNET/adenoma 55
  • Immature PIT1-lineage PitNET/adenoma 57
  • Acidophil stem cell PitNET/adenoma 59
  • Mixed somatotroph–lactotroph PitNET/adenoma 62
  • PitNETs of TPIT lineage Corticotroph PitNET/adenoma 65
  • PitNETs of SF1 lineage Gonadotroph PitNET/adenoma 70
  • PitNETs without distinct lineage differentiation Null cell PitNET/adenoma 73
  • Plurihormonal PitNET/adenoma 75
  • Multiple PitNETs
  • Multiple synchronous PitNETs/adenomas of distinct lineages 77
  • Metastatic PitNETs
  • Metastatic PitNET 79
  • Other anterior pituitary tumours
  • Adamantinomatous craniopharyngioma 82
  • Papillary craniopharyngioma 86
  • Pituitary blastoma 89
  • Posterior pituitary and hypothalamic neoplasms
  • Pituicyte-derived tumours
  • Pituicytomas 92
  • Neuronal tumours
  • Gangliocytoma and mixed gangliocytoma–PitNET/
  • adenoma 97
  • Sellar neurocytoma 100
  • Other sellar tumours
  • Meningiomas 103
  • Chordoma 105

3 Thyroid tumours

  • Introduction 108
  • Developmental abnormalities
  • Thyroglossal duct cyst 113
  • Other congenital thyroid abnormalities 116
  • Follicular cell–derived neoplasms
  • Benign tumours
  • Thyroid follicular nodular disease 119
  • Follicular thyroid adenoma 122
  • Follicular thyroid adenoma with papillary architecture 126
  • Oncocytic adenoma of the thyroid gland 129
  • Low-risk neoplasms
  • Non-invasive follicular thyroid neoplasm with papillary-like nuclear features 132
  • Thyroid tumours of uncertain malignant potential 135
  • Hyalinizing trabecular tumour 138
  • Malignant neoplasms
  • Follicular thyroid carcinoma 142
  • Invasive encapsulated follicular variant of papillary
  • thyroid carcinoma 147
  • Papillary thyroid carcinoma 150
  • Oncocytic carcinoma of the thyroid gland 161
  • High-grade follicular cell–derived non-anaplastic thyroid carcinoma 165
  • Anaplastic thyroid carcinoma 170
  • Thyroid C cell–derived carcinoma
  • Medullary thyroid carcinoma 174
  • Mixed medullary and follicular cell–derived carcinomas
  • Mixed medullary and follicular cell–derived thyroid
  • carcinoma 179
  • Salivary gland–type carcinomas of the thyroid gland
  • Mucoepidermoid carcinoma 182
  • Secretory carcinoma 184
  • Thyroid tumours of uncertain histogenesis
  • Sclerosing mucoepidermoid carcinoma with
  • eosinophilia 186
  • Cribriform morular thyroid carcinoma 189
  • Thymic tumours within the thyroid
  • Thymoma 192
  • Spindle epithelial tumour with thymus-like elements 194
  • Intrathyroidal thymic carcinoma 196
  • Embryonal thyroid neoplasms
  • Thyroblastoma 199

4 Parathyroid tumours 201

  • Introduction 202
  • Parathyroid hyperplasia 204
  • Parathyroid adenoma 207
  • Parathyroid lipoadenoma 213
  • Atypical parathyroid tumour 215
  • Parathyroid carcinoma 218

5 Adrenal gland tumours 223

  • Introduction 224
  • Lesions in the adrenal cortex
  • Adrenal rests 226
  • Contents
  • Adrenal cysts 228
  • Adrenal myelolipoma 230
  • Adrenal cortical tumours
  • Congenital adrenal hyperplasia 232
  • Adrenocortical nodular disease 236
  • Adrenal cortical adenoma 240
  • Adrenal cortical carcinoma 246
  • Sex cord stromal and other tumours
  • Adrenal sex cord stromal tumour 254
  • Adenomatoid tumour 256
  • Adrenal melanoma 258

6 Adrenal medulla and extra-adrenal paraganglia tumours 261

  • Introduction 262
  • Neuroblastic tumours
  • Neuroblastoma 265
  • Ganglioneuroblastoma, intermixed 271
  • Ganglioneuroblastoma, nodular 273
  • Ganglioneuroma 275
  • Paraganglioma and phaeochromocytoma
  • Phaeochromocytoma 277
  • Sympathetic paraganglioma 285
  • Parasympathetic paraganglioma 288
  • Composite paraganglion tumours
  • Composite phaeochromocytomas and
  • paragangliomas 292

7 Pancreatic neuroendocrine neoplasms 295

  • Introduction 296
  • Neuroendocrine neoplasms
  • Neuroendocrine tumours
  • Non-functioning (non-syndromic) pancreatic
  • neuroendocrine tumours 300
  • Insulinoma 305
  • Glucagonoma 309
  • Somatostatinoma 312
  • Gastrinoma 315
  • VIPoma 317
  • Serotonin-producing tumours
  • with and without carcinoid syndrome 320
  • Other pancreatic neuroendocrine tumours with
  • ectopic hormone production 322
  • Neuroendocrine carcinomas
  • Pancreatic neuroendocrine carcinoma 325
  • Mixed neuroendocrine–non-neuroendocrine neoplasms
  • Mixed ductal adenocarcinoma–neuroendocrine
  • neoplasms 328
  • Mixed acinar–neuroendocrine carcinoma 330

8 Neuroendocrine neoplasms in non-endocrine organs 333

  • Introduction 334
  • Neuroendocrine neoplasms
  • Neuroendocrine tumours
  • Neuroendocrine tumours 337
  • Neuroendocrine carcinomas
  • Small cell neuroendocrine carcinoma 339
  • Large cell neuroendocrine carcinoma 342
  • Merkel cell carcinoma 346
  • Mixed neuroendocrine neoplasms
  • Mixed neuroendocrine–non-neuroendocrine
  • neoplasms 348
  • Paraganglioma-like neuroendocrine neoplasms
  • Composite gangliocytoma/neuroma and
  • neuroendocrine tumour 351
  • Cauda equina neuroendocrine tumour (previously
  • paraganglioma) 354

9 Mesenchymal and stromal tumours 357

  • Introduction 358
  • Lipocytic tumours
  • Lipoma 359
  • Fibrous tumours
  • Solitary fibrous tumour 360
  • Vascular tumours
  • Benign vascular tumours 362
  • PEComa 364
  • Glomangioma and glomus tumour 366
  • Angiosarcoma 368
  • Smooth muscle tumours
  • Leiomyoma 371
  • Leiomyosarcoma 373
  • Skeletal muscle tumours
  • Rhabdomyosarcomas 376
  • Peripheral nerve sheath tumours
  • Schwannoma 379
  • Neurofibroma 381
  • Granular cell tumour 383
  • Malignant peripheral nerve sheath tumour 385

10 Haematolymphoid tumours 387

  • Introduction 388
  • IgG4-related disease 389
  • Extranodal marginal zone lymphoma of
  • mucosa-associated lymphoid tissue 392
  • Diffuse large B-cell lymphoma NOS 395
  • Langerhans cell histiocytosis 397
  • Rosai–Dorfman disease 400
  • Erdheim–Chester disease 402
  • Follicular dendritic cell sarcoma 404

11 Germ cell tumours 407

  • Introduction 408
  • Germ cell tumours
  • Germ cell tumours in endocrine organs 409
  • Teratomas with endocrine differentiation 412

12 Metastasis 415

  • Introduction 416
  • Metastasis to the pituitary gland 417
  • Metastasis to the thyroid gland 419
  • Metastasis to the adrenal gland 422

13 Genetic tumour syndromes associated with endocrine lesions and tumours 425

  • Introduction 426
  • Multiple endocrine neoplasia type 1 429
  • Multiple endocrine neoplasia type 2 435
  • Multiple endocrine neoplasia type 4 440
  • Multiple endocrine neoplasia type 5 (MAX-related
  • tumours) 444
  • Hyperparathyroidism–jaw tumour syndrome 448
  • Von Hippel–Lindau syndrome 452
  • SDH-deficient tumour syndromes 457
  • Neurofibromatosis type 1 463
  • Carney complex 466
  • McCune–Albright syndrome 471
  • DICER1 syndrome 474
  • Glucagon cell hyperplasia and neoplasia 478
  • MAFA-related familial insulinomatosis 480
  • Syndromic familial follicular cell–derived thyroid
  • tumours 482
  • Non-syndromic familial follicular cell–derived
  • thyroid tumours 488

  

  • Contributors 493
  • Declaration of interests 499
  • IARC/WHO Committee for ICD-O 500
  • Sources 501
  • References 507
  • Subject index 587
  • Previous volumes in the series 595

Auteur(s): ENDOCRINE AND NEUROENDOCRINE TUMOURS - WHO CLASSIFICATION OF TUMOURS 5TH Edition

International Agency for Research IARC

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