The anatomy and embryology of serous membranes are discussed, and the causes, epidemiology, and clinical and radiologic features of malignant mesothelioma are reviewed. A comprehensive review of immunostains used for diagnosing serous membrane lesions is given, current treatment options for patients are outlined. The markers of asbestos exposure and their significance are also assessed. The pathology of non-neoplastic conditions of serous membranes, from peritoneal cysts and endometriosis to deciduosis and gliomatosis peritonei are also covered, as are lymphomas and soft tissue tumors in serous membranes. This makes Practical Pathology of Serous Membranes an essential resource for effective diagnosis.