Pediatric Retina third edition

Dr. Mary Elizabeth Hartnett, along with internationally acclaimed physicians, surgeons, and scientists, guides you through today’s best practices for retinal diseases in infants and children. Hundreds of superb, full-color images (many new to this edition), as well as clinical videos online, provide clear visual support.

What is the content of "Pediatric Retina Third Edition" ?

• Covers the development of the eye and retina, relevant basic/translational science, telemedicine, international ophthalmology, and international approaches to care with focus on retinopathy of prematurity.
• Includes new and expanded information on pediatric retinal imaging, genetics, pathophysiology of disease, clinical diagnostics, and care including surgery, gene therapy, and methods to restore vision.
• Features an atlas of retinal images grouped by fundus appearance to aid in diagnosis.
• Discusses advances in posterior segment imaging with spectral domain hand-held OCT, along with endoscope in vitreoretinal surgery.

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Who is the author of "Pediatric Retina Third Edition" ?

Mary Elizabeth Hartnett MD, holds the Calvin S. and JeNeal N. Hatch Presidential Endowed Chair in Ophthalmology and Visual Sciences and is a Distinguished Professor at the University of Utah. She is an adjunct professor at the University of Utah departments of Neurobiology, Anatomy, and Pediatrics. Dr. Hartnett is the founder and director of Pediatric Retina at the John A. Moran Eye Center and principal investigator of the Retinal Angiogenesis Laboratory.

As director of Moran's Pediatric Retina Center, Dr. Hartnett is one of a few pediatric retina specialists internationally trained to diagnose and treat pediatric retina disorders, which disrupt the healthy development of the light-sensitive tissue at the back of the eye. There are dozens of conditions that cause retinal blindness in infants and children, but most are rare. She is one of only a handful of pediatric retina specialists in the United States offering complete care for these challenging conditions. She also practices as a vitreoretinal surgeon, providing treatment to patients throughout the Mountain West. She performs surgery at both the Moran Eye Center and Primary Children's Hospital.

Mary Elizabeth Hartnett, M.D. is the Principal Investigator of an NIH-funded laboratory that studies mechanisms of normal and aberrant angiogenesis, particularly related to diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration. The mission of the laboratory is to understand what causes blood vessels to grow outside their normal tissue compartments and into other areas of the eye where they cause damage. Rather than inhibit or destroy abnormal vessels, the goal is to understand what simulates endothelial cells of blood vessels to become activated to migrate and proliferate aberrantly, and once this is known, to then restore or contain blood vessel support to normal ocular compartments.

Dr. Hartnett and her team of researchers are investigating multiple causes of aberrant angiogenesis. One is retinal avascularity, or a lack of blood vessel support in areas of the inner retina that leads to retinal hypoxia, which stimulates aberrant growth of blood vessels. One important observation the Hartnett lab made was that overactivation of the signaling pathway of vascular endothelial growth factor (VEGF) actually contributes to retinal avascularity by disordering the growth of endothelial cells, causing them to grow into the gel of the eye (vitreous) as intravitreal neovascularization (IVNV, Fig 1, showing a retina flat-mount stained with lectin to visualize the vasculature) rather than normally into the retina. Another cause of abnormal angiogenesis is the generation of damaging reactive oxygen species, which can lead to loss of the integrity of the cell junctions, which are important in maintaining normal compartmentalization of tissues.