DIAGNOSTIC PATHOLOGY : MOLECULAR ONCOLOGY 3RD ED

DIAGNOSTIC PATHOLOGY : MOLECULAR ONCOLOGY 3RD ED

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training.

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Auteur(s) Mohammad A. Vasef, Aaron Auerbach
Éditeur ELSEVIER HEALTH SCIENCES
Collection Diagnostic Pathology
Date 12/03/2024
Pages 1016
Taille 21 x 27
Type Relié
ISBN 9780443112201

Description détaillée : DIAGNOSTIC PATHOLOGY : MOLECULAR ONCOLOGY 3RD ED

Providing a clear understanding of molecular pathology as it relates to the transformation and pathogenesis of cancer in an era of personalized medicine, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice.

Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Molecular Oncology is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, molecular pathologist, oncologist, or pathologist in training as an ideal day-to-day reference or as a reliable learning resource. 

New to this edition

Molecular oncology is a rapidly evolving field with tremendous amounts of information that is new since the 2e published in March 2019. There is new molecular genetic data linked to either new targeted therapies or that serves as diagnostic or prognostic indicators.

The 3e will include 8-10 new chapters and substantial updates and rewrites to existing contents to make sure ongoing edits and revisions to the upcoming WHO Classification of Hematopoietic Tumors are included in the 3e.

The authors provide guidance on selecting the right test(s) at the right time for the right patient and comparisons of molecular testing methods (i.e., FSH testing vs. cytogenetics) are included.

The market lacks a definitive source of all the recent changes, and DP3 Molecular Oncology will provide a comprehensive information source.

What are the Key Features of "Diagnostic Pathology : Molecular Oncology 3rd Edition" ?

  • Provides up-to-date, comprehensive coverage of relevant molecular tests and their clinical applications, along with organ-based chapters on the molecular genetic data relevant to individual disease entities
  • Contains new chapters and substantial revisions to existing content that include updates from the 2022 International Consensus Classification and the 5th edition WHO Classification of Hematolymphoid Tumors
  • Provides expert guidance on selecting the right test(s) at the right time, as well as comparisons of molecular testing methods (FISH vs. cytogenetics, for example)
  • Includes current information for new actionable mutations and targeted therapies
  • Covers ultrasensitive molecular techniques for minimal residual disease detection and disease monitoring
  • Discusses circulating cell-free DNA analysis for detection of resistance-associated mutations and disease monitoring, and provides usage details
  • Features an image-rich layout with more than 2,400 print and online images, including high-resolution H&E stains, immunostains, FISH images, gross pathology and clinical photographs, detailed full-color medical illustrations, and informative diagrams, charts, and schematics
  • Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care
  • Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud

Who are the Authors of "Diagnostic Pathology : Molecular Oncology 3rd Edition" ?

Mohammad A. Vasef, MD, Professor, Department of Pathology, Director of MGP Fellowship Program, Medical Director of Molecular Diagnostics, University of New Mexico/Tricore Ref Lab, Albuquerque, New Mexico, USA

Aaron Auerbach, MD, MPH, Senior Hematopathologist, Joint Pathology Center, Silver Spring, Maryland, USA

Sommaire : DIAGNOSTIC PATHOLOGY : MOLECULAR ONCOLOGY 3RD ED

SECTION 1: INTRODUCTION

4 Structure of Chromosomes and Nucleic Acids

Jeremy C. Wallentine, MD

8 DNA Replication, Transcription, and Translation

Jeremy C. Wallentine, MD

12 Gene Mutations

Jeremy C. Wallentine, MD

SECTION 2: COMMON TECHNIQUES FOR ANALYSIS OF ALTERATIONS IN CHROMOSOMES AND DNA

18 Cytogenetics and FISH

Mohammad A. Vasef, MD and David R. Czuchlewski, MD

22 Chromosomal Microarray

Sibel Kantarci, PhD, Durga Cherukuri, PhD, and

Mohammad A. Vasef, MD

26 Amplification Methods

Devon Chabot-Richards, MD

30 DNA High-Resolution Melting Curve Analysis

Amer Mahmoud, MD, FCAP

32 Sequencing Technologies

Eric Y. Loo, MD and Mohammad A. Vasef, MD

36 High-Throughput Methods in Molecular Pathology

Rama Gullapalli, MD, PhD

38 DNA Methylation Analysis

Devon Chabot-Richards, MD

SECTION 3: MOLECULAR GENETIC TESTS IN HEMATOPOIETIC TUMORS

42 BCR::ABL1 Fusion Gene

Eric Y. Loo, MD and Mohammad A. Vasef, MD

46 PML::RARA Fusion Gene

Devon Chabot-Richards, MD

48 Reverse Transcription PCR for Other Myeloid

Leukemia Transcripts

Kristin Hunt Karner, MD

50 FLT3, NPM1, and CEBPA Mutations

Devon Chabot-Richards, MD

54 JAK2 Mutations and Rearrangements

Mohammad A. Vasef, MD

56 MPL Mutations

Eric Y. Loo, MD and David R. Czuchlewski, MD

58 Calreticulin (CALR) Mutations

Eric Y. Loo, MD and Mohammad A. Vasef, MD

60 CSF3R Mutations

Amer Mahmoud, MD, FCAP

62 SETBP1 Mutations

Amer Mahmoud, MD, FCAP

64 KIT Mutations

Eric Y. Loo, MD and Mohammad A. Vasef, MD

68 IDH1 and IDH2 Mutations

Eric Y. Loo, MD and David R. Czuchlewski, MD

70 Other Mutations and Gene Panel Testing in Myeloid Neoplasms

Mohammad A. Vasef, MD and David R. Czuchlewski, MD

72 Immunoglobulin Heavy (IGH) Chain Gene

Rearrangements

Mohammad A. Vasef, MD and Anna P. Matynia, MD

76 T-Cell Receptor Gamma (TRG) and Delta (TRD) Chain

Rearrangements

Mohammad A. Vasef, MD and Anna P. Matynia, MD

80 T-Cell Receptor Beta (TRB) Chain Gene

Rearrangements

Mohammad A. Vasef, MD and Anna P. Matynia, MD

84 Southern Blot Analysis of Antigen Receptor Genes

Mohammad A. Vasef, MD

86 EBV-Associated Human Neoplasms

Mohammad A. Vasef, MD

94 MYD88 Mutation

Giovanni Insuasti-Beltran, MD

96 NOTCH1 Mutation

Giovanni Insuasti-Beltran, MD

98 EZH2 Mutation

Amer Mahmoud, MD, FCAP

SECTION 4: MOLECULAR GENETIC TESTS IN SOLID TUMORS, BONE AND SOFT TISSUE TUMORS, AND CNS TUMORS

104 ALK Gene Rearrangements and Mutations

Guanghua Wang, MD

106 ROS1 Rearrangements

Mohammad A. Vasef, MD and David R. Czuchlewski, MD

108 RET Rearrangements

Eric Y. Loo, MD and David R. Czuchlewski, MD

110 FISH for MET Amplifications

Devon Chabot-Richards, MD

114 FISH for ERBB2 (HER2) Gene Amplifications

Kristin Hunt Karner, MD

116 KRAS Mutations

Guanghua Wang, MD

118 BRAF Mutations

Yongjie Zhou, MD, PhD and Guanghua Wang, MD

120 EGFR Mutations

Guanghua Wang, MD

122 Targeted Hotspot Gene Panel Using Massively Parallel Sequencing (Next-Generation Sequencing)

Mohammad A. Vasef, MD and David R. Czuchlewski, MD

124 Targeted Hotspot Gene Panel Table

Mohammad A. Vasef, MD and David R. Czuchlewski, MD

130 MGMT Promoter Gene Methylation Assay

Devon Chabot-Richards, MD

SECTION 5: MOLECULAR PATHOLOGY OF MYELOID NEOPLASMS

134 Molecular Work-Up of Myeloid Neoplasms

Mohammad A. Vasef, MD and David R. Czuchlewski, MD

MYELOPROLIFERATIVE NEOPLASMS

136 Clonal Hematopoiesis and Pre-Malignant Clonal Cytopenia

Mohammad A. Vasef, MD

140 Chronic Myeloid Leukemia, BCR-ABL1 Positive

Mohammad A. Vasef, MD, Kaaren K. Reichard, MD, and David R. Czuchlewski, MD

148 Chronic Neutrophilic Leukemia

Devon Chabot-Richards, MD and David R. Czuchlewski, MD

152 Polycythemia Vera

Mohammad A. Vasef, MD and M. Carmen Frias Kletecka, MD

156 Primary Myelofibrosis

Devon Chabot-Richards, MD and Kaaren K. Reichard, MD

160 Essential Thrombocythemia

Giovanni Insuasti-Beltran, MD

164 Chronic Eosinophilic Leukemia, NOS

Devon Chabot-Richards, MD and Kaaren K. Reichard, MD

166 Myeloproliferative Neoplasms, Unclassifiable

Devon Chabot-Richards, MD and Kaaren K. Reichard, MD

MASTOCYTOSIS

170 Mastocytosis

Mohammad A. Vasef, MD

MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND GENE REARRANGEMENT

178 Myeloid/Lymphoid Neoplasms With Eosinophilia and Gene Rearrangement

Devon Chabot-Richards, MD and David R. Czuchlewski, MD

MYELODYSPLASTIC SYNDROME (MDS)

182 Overview and Classification of Myelodysplastic Syndrome

Devon Chabot-Richards, MD, David R. Czuchlewski, MD, and Carla S. Wilson, MD, PhD

186 Myelodysplastic Syndromes With Single-Lineage Dysplasia

Kristin Hunt Karner, MD

190 Myelodysplastic Syndrome With Ring Sideroblasts

Mohammad A. Vasef, MD and Carla

Auteur(s): DIAGNOSTIC PATHOLOGY : MOLECULAR ONCOLOGY 3RD ED

Mohammad A. Vasef
Aaron Auerbach
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