OCT angiography is a new functional imaging modality for clinical ophthalmology and fundamental research. Major topics of discussion include guide for interpreting OCT angiography in macular disease, age-related macular degeneration, diabetic retinopathy, macular telangictasia, myopia and other pathologies, as well as glaucoma and choroidal imaging. OCT angiography visualizes microvasculature by detecting motion contrast from blood flow. OCT angiography examinations can be performed rapidly, without patient discomfort and repeatedly and potentially on every patient visit to assess progression or treatment response. Successful interpretation of OCT angiography findings requires an understanding of how OCT angiography works, the association of different ocular pathologies with their angiographic features, and integrated assessment of angiographic and structural OCT image data.